Towards the end of the 1960s, the protestant observers of the Second Vatican Council had proposed the foundation of an ecumenical institution. The Valdese Faculty of Theology consolidated the proposal and strongly supported the project. In the 1980s in Germany, individuals and institutions of the theological world became so deeply involved that in 1997 concrete steps were taken for its implementation.

With the approval of the Methodist-Valdese Council of 2002 in Torre Pellice and the Lutheran Council of 2002 in Assisi, the Center was founded – also to the great joy of the Evangelical Church in Germany – by the Valdese Faculty, the Lutheran Evangelical Church in Italy and the Lutheran Evangelical Community in Rome.

In 2003, the association of “Friends of the Roman Melantone” (Freundeskreis Melanchthon Zentrum Rom e.V.)  was founded in Tubingen, Germany. It supports the activities of the Study Center and offers a platform for the students and all those interested.

The Study Center of Rome is an association with its official seat in Rome and is recognized by Italian law as the “Filippone Melantone Association Center – Protestant Ecumenical Study Center.”

In 2012, the first volume of the series, “Rome and Protestantism – Writings of Centro Melantone in Rome,” was published. The book contains the speeches of the 2009 international convention followed by many important conventions such as that on “Martin Luther in Rome” (2011).

In 2012 the Center celebrated its 10th anniversary. Throughout the years, hundreds of students have made use of the Center’s study offers.